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Med J Aust. 2001 May 21;174(10):492-6.

Childhood post-streptococcal glomerulonephritis as a risk factor for chronic renal disease in later life.

Author information

1
Menzies School of Health Research, Darwin, NT. Andrew.White@nt.gov.au

Abstract

OBJECTIVE:

To test the hypothesis that post-streptococcal glomerulonephritis (PSGN) in childhood is a risk factor for chronic renal disease in later life.

DESIGN:

Retrospective cohort study.

SETTING:

A remote Aboriginal community in the "Top End" of the Northern Territory that experienced two epidemics of PSGN in 1980 and 1987, respectively.

PARTICIPANTS:

472 people who were aged 2-15 years during either epidemic. They were categorised by clinical features recorded during the epidemics as having clinically defined PSGN (63), "abnormal urine" (haematuria or proteinuria; 86) or controls (323).

OUTCOME MEASURES:

Urinary albumin to creatinine ratio (ACR), haematuria (by dipstick urinalysis), blood pressure, serum creatinine level, and calculated glomerular filtration rate (GFR) during community screening in 1992-1998.

RESULTS:

Overt albuminuria (ACR > 34 mg/mmol) was present at follow-up in 13% of the PSGN group, 8% of the abnormal urine group, and 4% of the control group. The odds ratio (OR) for overt albuminuria in those with a history of PSGN compared with the control group, adjusted for age and sex, was 6.1 (95% CI, 2.2-16.9). Haematuria (>trace) was present in 21% of the PSGN group compared with 7% of the control group (adjusted OR, 3.7; 95% CI, 1.8-8.0). There were no significant differences between the groups in blood pressure, serum creatinine level or calculated GFR.

CONCLUSION:

In this population, a history of PSGN in childhood is a risk factor for albuminuria and haematuria in later life.

PMID:
11419767
[Indexed for MEDLINE]
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