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Microbes Infect. 2001 Jun;3(7):561-9.

The Yersinia high-pathogenicity island: an iron-uptake island.

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Laboratoire des Yersinia, Unité des bactériologie moléculaire et médicale, Institut Pasteur, 28, rue du Dr. Roux, 75724 cedex 15, Paris, France.


Highly pathogenic Yersinia carry a pathogenicity island termed high-pathogenicity island (HPI). The Yersinia HPI comprises genes involved in the synthesis of the siderophore yersiniabactin and can thus be regarded as an iron-uptake island. A unique characteristic of the HPI is its wide distribution among different enterobacteria such as Escherichia coli, Klebsiella, Citrobacter and Salmonella. Other types of iron-uptake systems are also carried by different pathogenicity islands in enterobacteria.

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