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Trends Genet. 2001 Jul;17(7):388-91.

Genetical genomics: the added value from segregation.

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Plant Research International BV, PO Box 16, NL-6700 AA, Wageningen, The Netherlands.


The recent successes of genome-wide expression profiling in biology tend to overlook the power of genetics. We here propose a merger of genomics and genetics into 'genetical genomics'. This involves expression profiling and marker-based fingerprinting of each individual of a segregating population, and exploits all the statistical tools used in the analysis of quantitative trait loci. Genetical genomics will combine the power of two different worlds in a way that is likely to become instrumental in the further unravelling of metabolic, regulatory and developmental pathways.

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