Abstract
Cdc42, a small GTPase, regulates actin polymerization and other signaling pathways through interaction with many different downstream effector proteins. Most of these effector proteins contain a Cdc42-binding domain, called a CRIB domain. Here, we describe the evolutionary analysis of these CRIB-containing proteins in yeast, worms, flies and humans. The number of CRIB-containing effector proteins increases from yeast to humans, involving both an increase within families and the emergence of new families. These evolutionary changes correlate with the development of the more complex signaling pathways present in higher organisms.
MeSH terms
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Animals
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Binding Sites
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Carrier Proteins / chemistry*
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Carrier Proteins / metabolism*
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Cell Cycle Proteins / chemistry
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Cell Cycle Proteins / metabolism
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Drosophila
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Evolution, Molecular*
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GTPase-Activating Proteins / chemistry
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GTPase-Activating Proteins / metabolism
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Guanosine Triphosphate / metabolism
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Humans
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Nuclear Proteins / chemistry
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Nuclear Proteins / metabolism
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Phosphoproteins / chemistry
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Phosphoproteins / metabolism
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Phylogeny
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Protein Serine-Threonine Kinases / chemistry
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Protein Serine-Threonine Kinases / metabolism
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Protein Structure, Tertiary
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Signal Transduction
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Yeasts
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cdc42 GTP-Binding Protein / genetics
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cdc42 GTP-Binding Protein / metabolism*
Substances
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Carrier Proteins
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Cell Cycle Proteins
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GTPase-Activating Proteins
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Nuclear Proteins
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Phosphoproteins
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Guanosine Triphosphate
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Protein Serine-Threonine Kinases
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cdc42 GTP-Binding Protein