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Org Lett. 2001 Jun 28;3(13):1969-72.

Asymmetric synthesis of an (R)-cyanohydrin using enzymes entrapped in lens-shaped gels.

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Degussa AG, Project House Biotechnology, Rodenbacher Chaussee 4, 63457 Hanau-Wolfgang, Germany.


[structure: see text] A novel synthesis of (R)-cyanohydrins is described which is based on the use of cross-linked and subsequently poly(vinyl alcohol)-entrapped (R)-oxynitrilases. These immobilized lens-shaped biocatalysts have a well-defined macroscopic size in the mm range, show no catalyst leaching, and can be recycled efficiently. Furthermore, this immobilization method is cheap and the entrapped (R)-oxynitrilases gave similar good results compared with those of free enzymes. The (R)-cyanohydrin was obtained in good yields and with high enantioselectivities of up to >99% ee.

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