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Nat Rev Mol Cell Biol. 2000 Oct;1(1):72-6. doi: 10.1038/35036093.

Hayflick, his limit, and cellular ageing.

Author information

1
University of Texas Southwestern Medical Center at Dallas, Department of Cell Biology, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9039, USA. shay@utsw.swmed.edu

Abstract

Almost 40 years ago, Leonard Hayflick discovered that cultured normal human cells have limited capacity to divide, after which they become senescent -- a phenomenon now known as the 'Hayflick limit'. Hayflick's findings were strongly challenged at the time, and continue to be questioned in a few circles, but his achievements have enabled others to make considerable progress towards understanding and manipulating the molecular mechanisms of ageing.

PMID:
11413492
DOI:
10.1038/35036093
[Indexed for MEDLINE]

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