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Nat Rev Mol Cell Biol. 2000 Oct;1(1):22-30.

A tale of toroids in DNA metabolism.

Author information

1
The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA. manju@mod.rockefeller.edu

Abstract

A strikingly large number of the proteins involved in DNA metabolism adopt a toroidal -- or ring-shaped -- quaternary structure, even though they have completely unrelated functions. Given that these proteins all use DNA as a substrate, their convergence to one shape is probably not a coincidence. Ring-forming proteins may have been selected during evolution for advantages conferred by the toroidal shape on their interactions with DNA.

PMID:
11413486
DOI:
10.1038/35036044
[Indexed for MEDLINE]

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