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Nat Rev Mol Cell Biol. 2001 Jan;2(1):67-71.

The mitochondrion in apoptosis: how Pandora's box opens.

Author information

1
Centre National de la Recherche Scientifique, UMR1599, Institut Gustave Roussy, 39 rue Camille-Desmoulins, F-94805 Villejuif, France.

Abstract

There is widespread agreement that mitochondria have a function in apoptosis, but the mechanisms behind their involvement remain controversial. Here we suggest that opening of a multiprotein complex called the mitochondrial permeability transition pore complex is sufficient (and, usually, necessary) for triggering apoptosis.

PMID:
11413468
DOI:
10.1038/35048073
[Indexed for MEDLINE]

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