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Curr Biol. 2001 Apr 3;11(7):R253-6.

Meiotic recombination: breaking the genome to save it.

Author information

1
Laboratory of Biochemistry, National Cancer Institute, Building 37 Room 6124, Bethesda, Maryland 20892-4255, USA. lichten@helix.nih

Abstract

Recombination ensures the correct segregation of chromosomes to gametes during meiosis. Recent studies point to a universal mechanism for initiating meiotic recombination: the formation of double-strand DNA breaks by Spo11p.

PMID:
11413012
DOI:
10.1016/s0960-9822(01)00131-2
[Indexed for MEDLINE]
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