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Bioorg Med Chem Lett. 2001 Jun 18;11(12):1613-7.

Novel alkylpolyamine analogues that possess both antitrypanosomal and antimicrosporidial activity.

Author information

1
Department of Pharmaceutical Sciences, Wayne State University, Detroit, MI 48202, USA.

Abstract

A novel series of alkyl- or aralkyl-substituted polyamine analogues was synthesized containing a 3-7-3 polyamine backbone. These analogues were evaluated in vitro, and in one case in vivo, for activity as antitrypanosomal agents, and for activity against opportunistic infection caused by Microsporidia. Compound 21 inhibits trypanosomal growth with an IC(50) as low as 31nM, while compound 24 shows promising activity in vitro against trypanosomes, and against Microsporidia in vitro and in vivo.

PMID:
11412992
PMCID:
PMC3109676
DOI:
10.1016/s0960-894x(01)00315-8
[Indexed for MEDLINE]
Free PMC Article

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