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Bioorg Med Chem Lett. 2001 Jun 18;11(12):1579-82.

Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme.

Author information

1
Department of Medicinal Chemistry, University of Kansas, 4060 Malott Hall, 1251 Wescoe Hall Drive, Lawrence, KS 66045-7582, USA. ggrunewald@ukans.edu

Abstract

Epinephrine (Epi) acts as a neurotransmitter in the brain, but its function therein is not well understood. Phenylethanolamine N-methyltransferase (PNMT) catalyzes the final step in the biosynthesis of Epi and is thus a pharmacological target to investigate the function of Epi in the central nervous system. The kinetic differences between bovine adrenal PNMT and human brain PNMT for a number of substrates and inhibitors are examined and the results reported.

PMID:
11412985
DOI:
10.1016/s0960-894x(01)00245-1
[Indexed for MEDLINE]

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