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FEBS Lett. 2001 Jun 8;498(2-3):219-22.

Antibiotic activities of peptides, hydrogen peroxide and peroxynitrite in plant defence.

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Departamento de Biotecnología - UPM, ETS Ingenieros Agrónomos, E-28040, Madrid, Spain.


Genes encoding plant antibiotic peptides show expression patterns that are consistent with a defence role. Transgenic over-expression of defence peptide genes is potentially useful to engineer resistance of plants to relevant pathogens. Pathogen mutants that are sensitive to plant peptides in vitro have been obtained and a decrease of their virulence in planta has been observed, which is consistent with their hypothetical defence role. A similar approach has been followed to elucidate the potential direct anti-microbial role of hydrogen peroxide. Additionally, a scavenger of peroxynitrite has been used to investigate its involvement in plant defence.

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