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Psychiatr Genet. 2001 Mar;11(1):11-7.

No association between serotonin 2A receptor gene variants and personality traits.

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  • 1Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.


Among theories of biological underpinnings to personality traits, different mechanisms of the serotonergic system are perhaps the most common factors suggested to influence individual differences in personality traits. We have investigated two frequent variants in the serotonin 2A receptor gene (5-HT2A) and personality traits. Healthy Swedish subjects (n = 304) were assessed with the Karolinska Scales of Personality (KSP) inventory. After correction for multiple testing, no significant differences were found. We conclude that the investigated 5-HT2A gene variants do not significantly influence personality as assessed by the KSP in the present population.

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