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Int J Tuberc Lung Dis. 2001 Jun;5(6):546-50.

Increased resistance to ciprofloxacin and ofloxacin in multidrug-resistant mycobacterium tuberculosis isolates from patients seen at a tertiary hospital in the Philippines.

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Tropical Disease Foundation, Makati Medical Center, Legaspi Village, Makati City, Philippines.



A hospital-based study at the Makati Medical Center, Makati City, Philippines, a hyperendemic area for tuberculosis (TB).


To determine the susceptibility of Mycobacterium tuberculosis to ciprofloxacin and ofloxacin.


Retrospective analysis of drug susceptibility tests (DST) of M. tuberculosis isolated from 1995-2000.


Resistance to ciprofloxacin was 26.8%, ofloxacin 35.3%, and multidrug resistance (MDR) was 17.2%. Of the MDR strains, 51.4% were resistant to ciprofloxacin and ofloxacin. Acquired resistance was significantly higher for all first-line drugs and for ciprofloxacin, but not for ofloxacin. A significant increase in resistance to ciprofloxacin and ofloxacin was noted compared to 1989-1994, while resistance to the firstline drugs was not significantly different.


Ciprofloxacin and ofloxacin are now a significantly less effective alternative therapy in tuberculosis, particularly MDR-TB, due to a selection pressure from their widespread use in the treatment of TB and possibly other infections in the community, which is hyperendemic for tuberculosis.

[Indexed for MEDLINE]

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