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Ann Neurol. 2001 Jun;49(6):810-3.

Treatment of acute Nipah encephalitis with ribavirin.

Author information

1
Department of Medicine, University of Malaya Medical Centre, Lembah Pantai, Kuala Lumpur, Malaysia.

Abstract

Nipah virus, a newly identified paramyxovirus caused a severe outbreak of encephalitis in Malaysia with high fatalities. We report an open-label trial of ribavirin in 140 patients, with 54 patients who were managed prior to the availability of ribavirin or refused treatment as control. There were 45 deaths (32%) in the ribavirin arm; 29 deaths (54%) occurred in the control arm. This represents a 36% reduction in mortality (p = 0.011). There was no associated serious side effect. This study suggests that ribavirin is able to reduce the mortality of acute Nipah encephalitis.

PMID:
11409437
DOI:
10.1002/ana.1062
[Indexed for MEDLINE]

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