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Antimicrob Agents Chemother. 2001 Jul;45(7):2157-9.

Novel mutations in ndh in isoniazid-resistant Mycobacterium tuberculosis isolates.

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1
Department of Clinical Research, Singapore General Hospital, 169608 Singapore.

Abstract

Novel mutations in NADH dehydrogenase (ndh) were detected in 8 of 84 (9.5%) isoniazid (INH)-resistant isolates (T110A [n = 1], R268H [n = 7]), but not in 22 INH-susceptible isolates of Mycobacterium tuberculosis. Significantly, all eight isolates with mutations at ndh did not have mutations at katG, kasA, or the promoter regions of inhA or ahpC, except for one isolate. Mutations in ndh appear to be an additional molecular mechanism for isoniazid resistance in M. tuberculosis.

PMID:
11408244
PMCID:
PMC90621
DOI:
10.1128/AAC.45.7.2157-2159.2001
[Indexed for MEDLINE]
Free PMC Article
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