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Antimicrob Agents Chemother. 2001 Jul;45(7):2136-40.

Fluoroquinolone resistance in anaerobic bacteria following exposure to levofloxacin, trovafloxacin, and sparfloxacin in an in vitro pharmacodynamic model.

Author information

1
University of Minnesota, College of Pharmacy, Minneapolis, Minnesota 55455, USA.

Abstract

This investigation explored pharmacodynamic characteristics of fluoroquinolones against Bacteroides thetaiotamicron and the potential for development of resistance. An in vitro model was used to generate kill curves with three fluoroquinolones at various area under the concentration-time curve (AUC)/MIC ratios. Concentration-independent killing was observed. Increases in MICs were noted following exposure to fluoroquinolones at AUC/MIC ratios of 6 to 14.

PMID:
11408238
PMCID:
PMC90615
DOI:
10.1128/AAC.45.7.2136-2140.2001
[Indexed for MEDLINE]
Free PMC Article

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