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Plasmid. 2001 May;45(3):209-21.

Molecular characterization of the klebicin B plasmid of Klebsiella pneumoniae.

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1
Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06520, USA.

Abstract

The nucleotide sequence of a bacteriocin-encoding plasmid isolated from Klebsiella pneumoniae (pKlebB-K17/80) has been determined. The encoded klebicin B protein is similar in sequence to the DNase pyocins and colicins, suggesting that klebicin B functions as a nonspecific endonuclease. The klebicin gene cluster, as well as the plasmid backbone, is a chimera, with regions similar to those of pore-former colicins, nuclease pyocins and colicins as well as noncolicinogenic plasmids. Similarities between pKlebB plasmid maintenance functions and those of the colicin E1 plasmid suggest that pKlebB is a member of the ColE1 plasmid replication family.

PMID:
11407916
DOI:
10.1006/plas.2001.1519
[Indexed for MEDLINE]
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