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Phytother Res. 2001 Jun;15(4):319-22.

Studies on the antidiarrhoeal effect of dragon's blood from Croton urucurana.

Author information

1
Departamento de Fisiologia e Farmacologia, FM, Universidade Federal do CearĂ¡, C.P. 3157, 60430-270, Fortaleza, C.E., Brazil.

Abstract

The red sap obtained by slashing the bark of Croton urucurana Baill. (Euphorbiaceae), also known as dragon's blood, was screened for a possible antidiarrhoeal activity on castor oil-induced diarrhoea in rats, cholera toxin-induced intestinal secretion in mice and on small intestinal transit in mice. Dragon's blood at an oral dose of 600 mg/kg caused in marked inhibition of the diarrhoeal response following castor oil administration as well as the intestinal fluid accumulation promoted by cholera toxin. At a similar dose the red sap significantly inhibited the small intestinal transit which was, however, found to be independent of the opioid mechanism. These results suggest a potential usefulness of the red sap from Croton urucurana Baill. in the control of secretory diarrhoea associated pathologies.

PMID:
11406855
[Indexed for MEDLINE]

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