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Curr Opin Immunol. 2001 Jun;13(3):332-8.

Phosphoinositide 3-kinases in T lymphocyte activation.

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  • 1Department of Pharmacology, Bath University, Claverton Down, BA2 7AY, Bath, UK.


Biochemical experiments have established that the metabolism of inositol phospholipids by phosphoinositide 3-kinases (PI3Ks) and lipid-phosphatases is triggered by many receptors that control T lymphocyte function, including antigen-receptors, costimulatory molecules, cytokines and chemokines. Novel effectors of PI3K have been identified in the immune system and shown to be important in the control of lymphocyte activation. Moreover, key lipid-phosphatases have been identified that act to terminate or modulate PI3K signalling in cells of the immune system.

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