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Curr Opin Immunol. 2001 Jun;13(3):326-31.

Face off--the interplay between activating and inhibitory immune receptors.

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1
Department of Microbiology and Immunology and the Cancer Research Institute, University of California (San Francisco), 513 Parnassus Avenue, Box 0414, 94143-0414, San Francisco, CA, USA. lanier@itsa.ucsf.edu

Abstract

The function of leukocytes is regulated by the integration of positive and negative signals received through cell surface receptors. Related receptors with similar extracellular domains and often binding the same ligands can transmit either inhibitory or activating signals. Studies are beginning to reveal how these 'paired receptors' control immune functions.

PMID:
11406364
[Indexed for MEDLINE]
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