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Curr Opin Immunol. 2001 Jun;13(3):286-90.

Reprogramming T cells: the role of extracellular matrix in coordination of T cell activation and migration.

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1
The Molecular Pathogenesis Program, Skirball Institute of Molecular Medicine and the Department of Pathology, New York University School of Medicine, 540 First Avenue, 10016, New York, NY, USA. dustin@saturn.med.nyu.edu

Abstract

The stable immunological synapse between a T cell and antigen-presenting cell coordinates migration and activation. Three-dimensional collagen gels transform this interaction into a series of transient hit-and-run encounters. Here we integrate these alternative modes of interaction in a model for primary T cell activation and effector function in vivo.

PMID:
11406359
[Indexed for MEDLINE]
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