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Curr Opin Immunol. 2001 Jun;13(3):286-90.

Reprogramming T cells: the role of extracellular matrix in coordination of T cell activation and migration.

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The Molecular Pathogenesis Program, Skirball Institute of Molecular Medicine and the Department of Pathology, New York University School of Medicine, 540 First Avenue, 10016, New York, NY, USA.


The stable immunological synapse between a T cell and antigen-presenting cell coordinates migration and activation. Three-dimensional collagen gels transform this interaction into a series of transient hit-and-run encounters. Here we integrate these alternative modes of interaction in a model for primary T cell activation and effector function in vivo.

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