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Curr Opin Biotechnol. 2001 Jun;12(3):254-8.

Microbial dehalogenation.

Author information

1
Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, NL-9747 AG, Groningen, The Netherlands. d.b.janssen@chem.rug.nl

Abstract

Novel dehalogenases have been identified recently in various bacteria that utilise halogenated substrates. X-ray studies and sequence analysis have revealed insight into the molecular mechanisms of hydrolytic dehalogenases. Furthermore, genetic and biochemical studies have indicated that reductive dehalogenases are extra-cytoplasmic corrinoid-containing iron-sulphur proteins. Sequence analysis and mutagenesis studies indicate that several dehalogenases are homologous to enzymes that carry out transformations on non-halogenated substrates.

PMID:
11404103
DOI:
10.1016/s0958-1669(00)00208-1
[Indexed for MEDLINE]

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