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J Clin Pharmacol. 2001 Jun;41(6):691-4.

Low molecular weight heparin-induced liver toxicity.

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Department of Medicine, University of Hong Kong, Queen Mary Hospital, 102, Pokfulam Road, Hong Kong, China.


The authors report two cases of hepatotoxicity induced by low molecular weight heparin. A 26-year-old woman and a 33-year-old man were treated with low molecular weight heparin for pulmonary embolism and cerebral infarction, respectively. They both developed derangement in liver function tests a few days after commencement of the low molecular weight heparin. The derangement in liver function tests was associated with a decreased serum complement 3 activity. Their liver functions recovered over a period of 2 to 3 months after low molecular weight heparin was stopped. Liver biopsy in the woman demonstrated balloon degeneration with scattered foci of hepatocytic necrosis, suggesting a complement-mediated hepatocellular damage.

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