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J Clin Pharmacol. 2001 Jun;41(6):655-61.

Pharmacokinetics of metformin gastric-retentive tablets in healthy volunteers.

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DepoMed, Inc., 1360 O'Brien Drive, Menlo Park, CA 94025-1436, USA.


The single-dose pharmacokinetics of two gastric-retentive, extended-release tablet formulations of metformin hydrochloride in fed, healthy volunteers were compared with those of the currently marketed immediate-release metformin hydrochloride product. The plasma concentration-time profiles demonstrated extended-release characteristics from the gastric-retentive tablets. The mean bioavailability from each gastric-retentive tablet was approximately 115%, relative to the immediate-release (IR) product. Cmax values were lower and tmax values were greater for the gastric-retentive tablets compared with the IR product. In contrast to conventional extended-release metformin tablets reported in the literature, these gastric-retentive tablets showed extended-release plasma concentration profiles of metformin hydrochloride and increased bioavailability compared with the immediate-release tablet.

[Indexed for MEDLINE]

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