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Neurology. 2001 Jun 12;56(11):1593-5.

The angiotensin I converting enzyme gene as a susceptibility factor for dementia.

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INSERM Unité 508, Institut Pasteur de Lille, France.


The frequency of a genetic susceptibility vascular factor, the deletion (D) allele of the angiotensin I converting enzyme gene (ACE), coding for a key enzyme of the renin angiotensin system, was characterized in two independent case--control studies. The results of the current study suggest that bearing at least one ACE D allele is a risk factor to develop dementia for subjects older than 74 years. This observation reinforces the hypothesis of a major implication of vascular risk factors in the occurrence of all types of dementia.

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