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Acta Psychiatr Scand. 2001 Jun;103(6):411-27.

The genetics of autism.

Author information

1
Department of Psychiatric Demography, Institute for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, Aarhus University Hospital, DK-8240 Risskov, Denmark.

Abstract

OBJECTIVE:

To review systematically the empirical evidence for the involvement of genetic risk factors in infantile autism.

METHOD:

We aimed at including all relevant papers written in English. We conducted a Medline search in September 2000. In addition we searched the reference lists of related papers.

RESULTS:

A relatively small number of reports including family and twin studies, comorbidity, cytogenetic and molecular genetic studies were reviewed.

CONCLUSION:

As well family, twin, cytogenetic and molecular genetic studies supported the importance of genetic risk factors in infantile autism. In most individual cases probably at least a few gene variants simultaneously determine the genetic risk. Presently the most interesting chromosome regions concerning the aetiology of autism are chromosomes 7q31-35, 15q11-13 and 16p13.3 which have been suggested by different lines of genetic research.

[Indexed for MEDLINE]

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