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JAMA. 2001 Jun 13;285(22):2888-90.

Association between apolipoprotein E epsilon4 and sleep-disordered breathing in adults.

Author information

1
Center for Narcolepsy, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305-5485, USA.

Abstract

CONTEXT:

Apolipoprotein E epsilon4(ApoE epsilon4) is a well-known risk factor for Alzheimer disease and cardiovascular disease. Sleep-disordered breathing occurs in Alzheimer disease patients and increases risks for cardiovascular disease. Complex interactions among sleep, brain pathology, and cardiovascular disease may occur in ApoE epsilon4 carriers.

OBJECTIVE:

To study whether genetic variation at the level of ApoE is associated with sleep-disordered breathing or sleep abnormalities in the general population.

DESIGN, SETTING, AND PARTICIPANTS:

Ongoing longitudinal cohort study of sleep disorders at a US university beginning in 1989, providing a population-based probability sample of 791 middle-aged adults (mean [SD] age, 49 [8] years; range, 32-68 years).

MAIN OUTCOME MEASURE:

Nocturnal polysomnography to evaluate apnea-hypopnea index.

RESULTS:

The probability of moderate-to-severe sleep-disordered breathing (apnea-hypopnea index >/=15%) was significantly higher in participants with epsilon4, independent of age, sex, body mass index, and ethnicity (12.0% vs 7.0%; P =.003). Mean (SEM) apnea-hypopnea index was also significantly higher in participants with ApoE epsilon4 (6.5 [0.6] vs 4.8 [0.3]; P =.01). These effects increased with the number of ApoE epsilon4 alleles carried.

CONCLUSIONS:

A significant portion of sleep-disordered breathing is associated with ApoE epsilon4 in the general population.

PMID:
11401610
DOI:
10.1001/jama.285.22.2888
[Indexed for MEDLINE]

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