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Indian J Gastroenterol. 2001 May-Jun;20(3):94-6.

Comparison of intradermal and intramuscular administration of hepatitis B vaccine in neonates.

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Department of Internal Medicine, Shiraz University of Medical Sciences, Islamic Republic of Iran.

Erratum in

  • Indian J Gastroenterol 2001 Sep-Oct;20(5):212.



Hepatitis B virus (HBV) infection and its complications are among the most common diseases in Iran. National mass vaccination of neonates against hepatitis B was started in 1991, but was considered a costly venture.


To compare the efficacy of low-dose intradermal HBV recombinant vaccine with standard intramuscular dose in neonates.


165 apparently healthy neonates born in Shiraz were randomized to receive either 10 microg [corrected] of recombinant vaccine intramuscularly (IM; n=82) or 2 microg [corrected] vaccine intradermally (ID; n=83) at months 0, 1, 6. Anti-HBs titers were measured at 6 and 18 months after the first dose.


53 and 51 neonates in the IM and ID groups, respectively, completed the study. Protective anti-HBs titers (>10 IU/L) at 18 months after the first dose were achieved in 98.1% and 96.2% of neonates in IM and ID groups, respectively (p=ns). The only side effect in the ID group was local hyperpigmentation, which was seen in 55%; no significant side effect was reported in the IM group.


Intradermal vaccination with 20% of standard dose is as effective as IM vaccination when evaluated at 18 months after the first dose.

[Indexed for MEDLINE]

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