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Curr Opin Neurobiol. 2001 Jun;11(3):387-94.

A neuron-glia signalling network in the active brain.

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Department of Pharmacological Sciences, Centre of Excellence for Neurodegenerative Disorders, University of Milan, Via Balzaretti 9,20133, Milan, Italy.


Glial cells are active partners of neurons in processing information and synaptic integration. They receive coded signals from synapses and elaborate modulatory responses. The active properties of glia, including long-range signalling and regulated transmitter release, are beginning to be elucidated. Recent insights suggest that the active brain should no longer be regarded as a circuitry of neuronal contacts, but as an integrated network of interactive neurons and glia.

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