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Curr Opin Neurobiol. 2001 Jun;11(3):327-35.

NMDA receptor subunits: diversity, development and disease.

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Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK.


N-methyl-D-aspartate receptors (NMDARs) are present at many excitatory glutamate synapses in the central nervous system and display unique properties that depend on their subunit composition. Biophysical, pharmacological and molecular methods have been used to determine the key features conferred by the various NMDAR subunits, and have helped to establish which NMDAR subtypes are present at particular synapses. Recent studies are beginning to address the functional significance of NMDAR diversity under normal and pathological conditions.

[Indexed for MEDLINE]

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