Format

Send to

Choose Destination
Curr Opin Neurobiol. 2001 Jun;11(3):287-96.

Neuregulin and ErbB receptor signaling pathways in the nervous system.

Author information

1
Section on Molecular Neurobiology, Building 49, Room 5A-38, National Institutes of Health, Bethesda, Maryland 20892-4480, USA. buonanno@helix.nih.gov

Abstract

The neuregulins are a complex family of factors that perform many functions during neural development. Recent experiments have shown that neuregulins promote neuronal migration and differentiation, and regulate the selective expression of neurotransmitter receptors in neurons and at the neuromuscular junction. They also regulate glial commitment, proliferation, survival and differentiation. At interneuronal synapses, neuregulin ErbB receptors associate with PDZ-domain proteins at postsynaptic densities where they can modulate synaptic plasticity. How this combinatorial network - comprising many neuregulin ligands that signal through distinct combinations of dimeric ErbB receptors - elicits its multitude of biological effects is beginning to be resolved.

PMID:
11399426
DOI:
10.1016/s0959-4388(00)00210-5
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center