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Curr Opin Neurobiol. 2001 Jun;11(3):281-6.

The uniqueness of being a neurotrophin receptor.

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  • 1Weill Medical College of Cornell University Medical College, New York, New York 10021, USA.


Neurotrophins rely on Trk tyrosine kinase and p75 receptors for signal transduction. Recently, other roles for these receptors have been identified. Many questions have been raised about the mechanism by which these receptors mediate diverse cellular functions. Studies indicate a great deal of neurotrophin signaling specificity may stem from ligand-receptor selectivity and intracellular protein recruitment.

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