Format

Send to

Choose Destination
Semin Immunol. 2001 Jun;13(3):163-76.

The role of epithelial cells in immune regulation in the gut.

Author information

1
Immunobiology Center, The Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA.

Abstract

A variety of mechanisms contribute to the ability of the gut to either react or remain tolerant to antigens present in the intestinal lumen. Intestinal epithelial cells can control the uptake, transmission and presentation of luminal antigens through an astonishingly diverse set of pathways. Antigens can cross the epithelial barrier via non-specific pinocytotic, specific receptor mediated, or intracellular/paracellular bypass pathways. The differential processing and presentation by a variety of restriction elements may result in the activation of functionally distinct target cell populations which have the capacity to regulate the predominant trend of immune unresponsiveness within the gut.

PMID:
11394959
DOI:
10.1006/smim.2000.0311
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center