Abstract
A 57-year-old woman was hospitalized with malignant lymphoma of the right talus. After treatment, complete remission was obtained. Gallium-67 scintigraphy to confirm the remission demonstrated increased uptake in the whole body skeletal muscle, especially in her thighs. Biopsy of right gastrocnemius muscle showed epithelioid granuloma. Serum angiotensin-converting enzyme activity (ACE) and lysozyme had increased to several times the normal range. We diagnosed her disease as bone-associated sarcoidosis-lymphoma syndrome. Human herpes virus 8 (HHV-8) genome was examined in the bone marrow specimen, and the relationship between sarcoidosis-lymphoma syndrome and HHV-8 was discussed.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Bone Marrow / virology
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Bone Neoplasms / diagnosis
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Bone Neoplasms / drug therapy
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Bone Neoplasms / etiology*
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Bone Neoplasms / pathology
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Cyclophosphamide / therapeutic use
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Doxorubicin / therapeutic use
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Female
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Gallium Radioisotopes
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Herpesvirus 8, Human / isolation & purification
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Humans
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Lymphoma / diagnosis
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Lymphoma / drug therapy
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Lymphoma / etiology*
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Lymphoma / pathology
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Middle Aged
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Prednisone / therapeutic use
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Radiography
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Radionuclide Imaging
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Sarcoidosis / complications*
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Syndrome
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Talus / diagnostic imaging
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Vincristine / therapeutic use
Substances
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Gallium Radioisotopes
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Vincristine
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Doxorubicin
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Cyclophosphamide
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Prednisone