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Life Sci. 2001 Apr 27;68(22-23):2489-93.

Alteration of cardiovascular and neuronal function in M1 knockout mice.

Author information

1
Department of Pharmacology, University of Washington, Seattle 98195-7750, USA.

Abstract

We used gene targeting to generate mice lacking the M1 muscarinic acetylcholine receptor. These mice exhibit a decreased susceptibility to pilocarpine-induced seizures, loss of regulation of M-current potassium channel activity and of a specific calcium channel pathway in sympathetic neurons, a loss of the positive chronotropic and inotropic responses to the novel muscarinic agonist McN-A-343, and impaired learning in a hippocampal-dependent test of spatial memory.

PMID:
11392617
DOI:
10.1016/s0024-3205(01)01043-8
[Indexed for MEDLINE]

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