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Bioorg Med Chem Lett. 2001 May 21;11(10):1257-60.

Diaryl ether inhibitors of farnesyl-protein transferase.

Author information

1
Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486. USA. sue_mactough@merck.com

Abstract

Imidazolemethyl diaryl ethers are potent inhibitors of farnesyl-protein transferase. The SNAr displacement reaction used to prepare these diaryl ethers was amenable to rapid parallel synthesis of FPTase inhibitors. The use of a broad range of commercially available phenols quickly identified compounds which proved active in cells.

PMID:
11392531
DOI:
10.1016/s0960-894x(01)00162-7
[Indexed for MEDLINE]

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