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Rinsho Byori. 2001 Apr;49(4):360-4.

[Involvement of interleukin-4, and -13 in the pathogenesis of allergic diseases].

[Article in Japanese]

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Department of Biochemistry, Saga Medical School, Saga 849-8501.


Allergic diseases are immunologic disorders in which various kinds of cells and many mediators are involved. Among them, the importance of interleukin(IL)-4 and IL-13 has recently emerged, based on the analyses of cytokine expression profiles in lesions, model mice, genetic factors, and responses to newly developed reagents. It is known that IL-4 and IL-13 are involved in the pathogenesis of allergic diseases, particularly bronchial asthma, by inducing class switching in B cells and expansion of Th2-type cells. However, IL-4 and IL-13 have a pivotal role in causing bronchial asthma by acting directly on bronchial tissues. Furthermore, it has been demonstrated that a single nucleotide polymorphism in the IL-13 gene is genetically correlated with bronchial asthma. These analyses provide new information for developing better methods of diagnosing and treating bronchial asthma.

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