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Int J Cancer. 2001 Jul 1;93(1):62-6.

Expression of multidrug-resistance P-glycoprotein (MDR1) in human brain tumors.

Author information

1
Laboratoire de Médecine Moléculaire, Hôpital Sainte-Justine-Université du Québec à Montréal, Montréal, Québec, Canada.

Abstract

Multidrug resistance (MDR) is associated with the expression of P-glycoprotein (P-gp), an ATP-dependent transporter which expels anti-cancer drugs from cells. In the present study, MDR1 P-gp was immunodetected by Western blot analysis in 60 human brain tumors, including meningiomas, schwannomas, low-grade gliomas (astrocytomas, pilocytic astrocytomas) and high-grade gliomas (anaplastic astrocytomas, glioblastomas and anaplastic oligodendrogliomas). Most samples from primary tumors expressed P-gp at the same levels as normal brain tissue except for schwannomas, in which levels were reduced by 65%, and meningiomas, in which levels were more than 10-fold higher in 7 of 10 samples. P-gp levels were 70% and 95% lower in brain metastases from melanomas and lung adenocarcinomas, respectively, than in normal brain tissue. These results indicate that the majority of primary brain tumors express MDR1 P-gp and that its high expression levels in meningiomas may be a marker for this type of brain tumor.

PMID:
11391622
DOI:
10.1002/ijc.1306
[Indexed for MEDLINE]
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