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News Physiol Sci. 2000 Jun;15:154-158.

Stimulatory and Inhibitory Functions of the R Domain on CFTR Chloride Channel.

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Department of Physiology and Biophysics at Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106.


CFTR is a chloride channel whose gating process involves coordinated interactions among the regulatory (R) domain and the nucleotide-binding folds (NBFs). Protein kinase A phosphorylation of serine residues renders the R domain from inhibitory to stimulatory and enables ATP binding and hydrolysis at the NBFs, which in turn control opening and closing of the chloride channel.


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