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News Physiol Sci. 1999 Jun;14:105-110.

Stimulation of Glucose Transport by Hypoxia: Signals and Mechanisms.

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Departments of Molecular Biology and Microbiology, Medicine, and Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106-4951, USA.


Glucose transport is acutely stimulated by hypoxia through enhanced GLUT-1 and GLUT-4 glucose transporter function. GLUT-1 expression is also stimulated by hypoxia or azide. Moreover, hypoxia per se, acting through hypoxia-inducible factor 1, enhances GLUT-1 transcription. GLUT-1 is the first gene whose transcription is dually stimulated in response to hypoxia and inhibition of oxidative phosphorylation.


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