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News Physiol Sci. 1999 Jun;14:87-92.

An Integrated View of Insect Flight Muscle: Genes, Motor Molecules, and Motion.

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Department of Molecular Physiology & Biophysics, University of Vermont, Burlington, VT 05405, USA.


Substituting an alanine for serine in the regulatory subunit of the motor protein myosin dramatically alters Drosophila's flight ability. Power output, at all levels of the flight system, is reduced. This example of deciphering a protein's function by producing malfunctions illustrates the broadening use of molecular genetics in integrative biology.


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