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News Physiol Sci. 1999 Feb;14:18-23.

Chemosensory Perception in the Gut.

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  • 1Institute of Anatomy, Julius Maximilians University, Koellikerstr. 6, D-97070 Würzburg, Germany.


The ability of the gut mucosa to sense the chemical composition of chyme is important for gastrointestinal functions. The demonstration of gustducin and transducin, two alpha-subunits of GTP-binding proteins involved in gustatory signal transduction, in gastrointestinal epithelial cells provides first clues to the molecular basis of enteric chemosensitivity. Nitric oxide may play a role as a secondary messenger.

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