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News Physiol Sci. 1998 Oct;13:211-217.

Calcium Channels Formed by Mammalian Trp Homologues.

Author information

1
Dept. of Pharmacology and the Neurobiotechnology Center, Ohio State Univ., Columbus, OH 43210, USA.

Abstract

Homologues of Drosophila trp genes have been isolated from mammalian species in hope that they may constitute the molecular basis of capacitative Ca(2+) entry. Expression of Trps suggests that they form Ca(2+) influx channels regulated by either store depletion or a more upstream event. Store-operated Trp channels can be formed by heteromultimerization.

PMID:
11390792

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