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Nat Rev Mol Cell Biol. 2001 Jun;2(6):457-66.

Living dangerously: how Helicobacter pylori survives in the human stomach.

Author information

1
Centro CNR Biomembrane e Dipartimento di Scienze Biomediche, Università di Padova, Via G. Colombo 3, 35121 Padova, Italy. cesare@civ.bio.unipd.it

Abstract

Helicobacter pylori was already present in the stomach of primitive humans as they left Africa and spread through the world. Today, it still chronically infects more than 50% of the human population, causing, in some cases, severe diseases such as peptic ulcers and stomach cancer. To succeed in these long-term associations, H. pylori has developed a unique set of virulence factors, which allow survival in a unique and hostile ecological niche--the human stomach.

PMID:
11389469
DOI:
10.1038/35073084
[Indexed for MEDLINE]

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