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Nat Rev Mol Cell Biol. 2001 Jun;2(6):433-43.

The junction-resolving enzymes.

Author information

1
CRC Nucleic Acid Structure Research Group, Department of Biochemistry, University of Dundee, Dundee DD1 5EH, UK. dmjlilley@bad.dundee.ac.uk

Abstract

Junction-resolving enzymes are ubiquitous nucleases that are important for DNA repair and recombination and act on DNA molecules containing branch points, especially four-way junctions. They show a pronounced selectivity for the structure of the DNA substrate but, despite its importance, the structural selectivity is not well understood. This poses an intriguing challenge in molecular recognition on a relatively large scale.

PMID:
11389467
DOI:
10.1038/35073057
[Indexed for MEDLINE]

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