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Nat Rev Mol Cell Biol. 2001 Jun;2(6):409-21.

Mechanisms of transcriptional memory.

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1
Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

Abstract

How can the same gene remember that it is 'off' in one cell lineage and 'on' in another? Studies of how homeotic genes are regulated in Drosophila melanogaster have uncovered a transcriptional maintenance system, encoded by the Polycomb and trithorax group genes, that preserves expression patterns across development. Here we try to formulate a broad framework for the types of molecular mechanism used by the Polycomb and trithorax proteins.

PMID:
11389465
DOI:
10.1038/35073039
[Indexed for MEDLINE]
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