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Nat Cell Biol. 2001 Jun;3(6):573-9.

Evidence that RME-1, a conserved C. elegans EH-domain protein, functions in endocytic recycling.

Author information

1
Columbia University College of Physicians and Surgeons, Department of Biochemistry and Molecular Biophysics, 630 West 168th Street, New York, New York 10032, USA. grant@cuccfa.ccc.columbia.edu

Abstract

In genetic screens for new endocytosis genes in Caenorhabditis elegans we identified RME-1, a member of a conserved class of Eps15-homology (EH)-domain proteins. Here we show that RME-1 is associated with the periphery of endocytic organelles, which is consistent with a direct role in endocytic transport. Endocytic defects in rme-1 mutants indicate that the protein is likely to have a function in endocytic recycling. Evidence from studies of mammalian RME-1 also points to a function for RME-1 in recycling, specifically in the exit of membrane proteins from recycling endosomes. These studies show a conserved function in endocytic recycling for the RME-1 family of EH proteins.

PMID:
11389442
DOI:
10.1038/35078549
[Indexed for MEDLINE]

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