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Nat Cell Biol. 2001 Jun;3(6):573-9.

Evidence that RME-1, a conserved C. elegans EH-domain protein, functions in endocytic recycling.

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Columbia University College of Physicians and Surgeons, Department of Biochemistry and Molecular Biophysics, 630 West 168th Street, New York, New York 10032, USA.


In genetic screens for new endocytosis genes in Caenorhabditis elegans we identified RME-1, a member of a conserved class of Eps15-homology (EH)-domain proteins. Here we show that RME-1 is associated with the periphery of endocytic organelles, which is consistent with a direct role in endocytic transport. Endocytic defects in rme-1 mutants indicate that the protein is likely to have a function in endocytic recycling. Evidence from studies of mammalian RME-1 also points to a function for RME-1 in recycling, specifically in the exit of membrane proteins from recycling endosomes. These studies show a conserved function in endocytic recycling for the RME-1 family of EH proteins.

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