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Org Lett. 2001 May 17;3(10):1543-5.

Novel bromotyrosine alkaloids: inhibitors of mycothiol S-conjugate amidase.

Author information

1
Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-0820, USA.

Abstract

[structure: see text] The novel alkaloids 1 and 4 were isolated from an Australian non-verongid sponge, Oceanapia sp. Compound 1 contains an unprecedented imidazolyl-quinolinone substructure attached to a bromotyrosine-derived spiro-isoxazoline. Three other known alkaloids were isolated in addition to 1 and 4 and together represent the first examples of inhibitors of a new mycobacterial enzyme mycothiol S-conjugate amidase (MCA).

PMID:
11388862
DOI:
10.1021/ol015845+
[Indexed for MEDLINE]

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