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Can J Psychiatry. 2001 May;46(4):356-8.

Olanzapine augmentation of serotonin uptake inhibitors in obsessive-compulsive disorder: an open study.

Author information

1
Department of Psychiatry, Center for Treatment of Anxiety Disorders, Morbegno, Italy. giofran@katamail.com

Abstract

OBJECTIVE:

This study evaluates the clinical response to olanzapine used in association with selective serotonin reuptake inhibitors (SSRIs) or clomipramine in treatment-resistant obsessive-compulsive disorder (OCD).

METHODS:

We describe the cases of 9 patients with serotonin uptake inhibitor-resistant OCD who were given an open-label adjunctive treatment of olanzapine for a minimum of 6 weeks. The response was assessed by using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and the Clinical Global Impression Scale (CGI).

RESULTS:

Six patients showed improvement of symptoms after the augmentation with olanzapine. One patient (treated with clomipramine) discontinued olanzapine due to side effects, and another 2 did not respond.

CONCLUSION:

Olanzapine augmentation of SSRIs in treating OCD showed a good (two-thirds) response rate, and it could therefore be considered as a treatment option when conventional therapies have failed.

PMID:
11387793
DOI:
10.1177/070674370104600408
[Indexed for MEDLINE]

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